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WHAT WE DO

Lateral Flow Assays offer simple, low-cost, portable, and rapid detection of of an analyte. These paper-based tests are can be performed in the field or at home with minimal training or equipment. In about 10 or 15 minutes after a sample is applied, a visual indicator denotes a positive result, negative result, or test error. This indicator usually takes the form of lines that must be visually interpreted by the operator.  


LFAs are convenient tests but lack sensitivity relative to laboratory test. For example, the visual detection limit of THC in commercially available LFAs is normally limited to greater than 25ng/ml, insufficient for proper enforcement of workplace regulations and drug-impaired driving laws. 


We have built a low-cost thermo-photonic technology to more accurately analyze commercially available low-cost LFAs. Our system offers detection and quantification of THC down to 2ng/ml with 96% accuracy.   

NOVEL TECHNOLOGY

Our photothermal detection technology employs laser stimulation and infrared sensors to more accurately measure the results of the assay. These methods are not limit to drug detection, but can be used in a wide variety of applications where antibody conjugates are already available.  


 Recently, our reader has been used in detection and quantification of the SARS-CoV-2 Antibody.  Our proof-of-concept results with humanized monoclonal anti-SARS-CoV-2 Spike receptor-binding domain (RBD) IgG demonstrate that the thermo-photonic technology can detect and quantify antibody concentrations within the clinically relevant range and with a limit of detection of 0.1μg /ml.


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Publications

Low cost active thermography using cellphone attachment infrared camera: from early detection of dental carries to quantification of THC in oral fluid

 

Thermographic detection and quantification of THC in oral fluid at unprecedented low concentrations

uspto.report/patent/grant/10,859,490

Patented Technology

 granted by the patent office  

 for system and method for photo-thermal analysis of immunoassay tests 

Journal

Enhancement of sensitivity and detection limit of lateral flow immunoassays using lock-in thermography 

Journal

Journal

Thermo-Photonic Detection of THC in Oral Fluid: Transition from Bench-Top System to Handheld Device

Journal

Journal

Journal

 High-sensitivity interpretation of lateral flow immunoassays using thermophotonic lock-in imaging

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Announce coming events

Announce coming events

 Handheld Thermo-Photonic Device for Rapid, Low-Cost, and On-Site Detection and Quantification of Anti-SARS-CoV-2 Antibody

Announce coming events

Announce coming events

Announce coming events

 Portable thermo-photonic device for highly sensitive detection and quantification of target analytes in lateral flow immunoassay 

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